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KMID : 0386420090220010045
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Journal of the Korean Fracture Society
2009 Volume.22 No. 1 p.45 ~ p.50
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The Effect of COX-2 Inhibitor on the Expression of MMP-13 during Early Fracture Healing Phase in Rats
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Kang Ki-Ser
Lee Han-Jun
Lee Jae-Sung
Ryu Ho-Sung
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Abstract
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Purpose: This study investigated the effect of COX-2 inhibitor on the expression of MMP-13 in the healing process of fracture.
Material and Methods: Adult Sprague-Dawley rats were divided into two groups of twenty five rats each. Unilateral femoral shaft fractures were created artificially under displacement in all two groups. COX-2 inhibitor was only given to the experimental group from the postoperative day 1. At 2 weeks after fracture the rats were sacrificed and the callus from each group was used for histologic examination and real time RT-PCR for MMP-13 expression.
Results: Histologically, proliferation of osteoblasts and formation of osteoid was less abundant in the experimental group. In real time RT-PCR, the mean expression of MMP-13 is 2.84±2.50 in the control group compared with 1.16±1.05 in the experimental group.
Conclusion: In the early stage of fracture healing, COX-2 inhibitor suppress the expression of MMP-13.
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KEYWORD
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Fracture, Healing, MMP-13, COX-2 Inhibitor
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